Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia
نویسندگان
چکیده
منابع مشابه
Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels.
A variety of direct and indirect techniques have revealed the existence of ATP-sensitive potassium (KATP) channels in the inner membranes of mitochondria. The molecular identity of these mitochondrial KATP (mitoKATP) channels remains unclear. We used a pharmacological approach to distinguish mitoKATP channels from classical, molecularly defined cardiac sarcolemmal KATP (surfaceKATP) channels en...
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BACKGROUND Cardiac dysfunction is well-described in endotoxemia and diagnosed in up to 60% of patients with endotoxic shock. ATP-sensitive potassium (KATP) channels are critical to cardiac function. This study investigates the role of Kir6.2 subunits of KATP channels on cardiac dysfunction in lipopolysaccharide (LPS)-induced endotoxemia. METHODS Kir6.2 subunits knockout (Kir6.2-/-) and wild-t...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2020
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-020-01946-3